The regulation of dietary supplements in the United States is complex and not well understood by the public. This course will examine the impact of laws that regulate dietary supplements, explore drug interactions when supplements are used with prescription medications, and investigate the role that dietary supplements can play in the development of serotonin syndrome. The distinction between adverse effects and allergies will also be considered in this educational activity. Pharmacy technicians who complete this course will have a solid foundation in dietary supplement regulation and important pharmacological concepts related to supplement use.