It’s time for a drug bracketology, a “Drug Madness,” to pit one drug against another. With absolutely no room for bias, pharmacology will rule as law of the land to ultimately crown “The Most Interesting Drug of All Time.” We’ll start with a “Sweet 16” of substances of abuse, mention a few bubble-busting first four out, and navigate our way through the “Elite 8” and “Final 4,” all while reviewing patient counseling-specific pharmacology clinical pearls. One drug will remain standing atop the mountain. We will also discuss more detail into the sensationalized actual “drug madness” permeating through our society in the “War on Drugs” including, but also well beyond, the “Opioid Crisis.”