Women’s health is a growing area of medicine and with that comes the need for compounded preparations which are designed appropriately for the female anatomy. Compounding for areas such as the vaginal mucosa or vulvovaginal region requires specialized preparations designed for those tissue sensitivities and absorption requirements. Inert ingredients, preservatives, bases used, and pH must all be taken into account with medications that are prescribed for vulvovaginal use. There is a need for training on what is appropriate for vaginal use, especially when it comes to nonsterile compounding and building appropriate preparations for the female anatomy.